Abstract

THE EFFECT OF HYPHEANE THEBAICA EXTRACT ON GENTAMICIN INDUCED RENAL FAILURE IN RATS

Ebtehal El Taher*, Sania Shaddad, A. K. Muddathir, Nuha M.E. Agabna, Amna E. H. Mohammed and Afaf I Abualgassim

Abstract

The effects of hot water infusion of the dried endocarp of Hypaene thebaica were examined on a group of albino rats. Animals were divided into four groups of six each; one was control, the second received gentamicin 100mg/kg to induce renal damage and served as positive control. The third group received gentamicin 100mg/ kg and 0.57mg/kg H. thebaica oral concurrently for eight days. The fourth group was given the extract oral for 21 days. Results showed that urea creatinine and potassium levels were significantly increased in group two and three indicating that H. thebaica did not protect the renal damage. However histopathologal study detected mild amelioration of nephronal damage. Liver enzymes were slightly elevated in the treated groups. Haematological parameters were restored in the H. thebaica group denoting that the extract had haematinic effects.

Keywords: Hypheane thebaica, gentamycin, renal failure, rats.