Abstract

ARIPIPRAZOLE NIOSOMAL SUSPENSION AS BRAIN TARGETTED DELIVERY SYSTEMS

Shaik Rizwana*, Medarametla Kishore Babu

Abstract

The objective of this research work is to formulate Aripiprazole niosomal suspensions to target the drug to the brain surpassing the Blood brain barrier and to increase the retention time in the brain for better therapy. The IR peaks of physical mixture containing Aripiprazole were mostly identical with the peaks of the pure sample of Aripiprazole indicating their compatibility. The niosomal suspensions containing Aripiprazole was formulated by thin film hydration technique using rotary vacuum flash evaporator with span 20, span 60, span 80 and varying ratios cholesterol in molecular weight ratios. When subjected to evaluation it was observed that maximum entrapment efficiency was achieved with span 60 and cholesterol formulations. In vitro diffusion studies of all the formulations followed first-order kinetics & ascertained Peppas mechanism. Application of Koryse Meyer Peppas equation to the data of the formulation revealed that mechanism of Aripiprazole niosomes was governed by predominant Non-fickian diffusion (slope>0.5). Based on the release profile and the entrapment efficiency, the Aripiprazole niosomal formulation F5 was found to be the optimized formulation.SEM analysis revealed that the particles appeared were spherical in shape. The particle size range of the niosomal formulation was from 392-1000nm with the average particle size of 557.6nm.The zeta potential of the optimized formulation (F5) was found to be -31.8mv indicating the higher negative surface charge claiming to possess good stability. From the above results it can be concluded that Aripiprazole niosomal suspension could act as better formulation for the effective management of psychotic disorders.

Keywords: Aripiprazole, Blood brain barrier, Niosomes, Psychosis.