Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL BENZIMIDAZOLE DERIVATIVES

A. Bouayyadi*, A. Moussaif, A. EL Hessni, A. Ouichou, B. Lakhrissi, N. EL Abbadi, M. Mzibri, A. Moutaouakkil, A. Iddar, Y. Ramlii, M. EL Faydy, A. Aiboud, A. Mesfioui and E.M. Essassi

Abstract

Benzimidazole and its derivatives are known for their manytherapeutic applications and represent one of the most biologicallyactive classes and especially psychotropic activity. They can be used inthe conditions of inflammation, microbial infections and also inpsychotropic diseases (depression and anxiety). In this way, a newmethod using Phase-Transfer Catalysis (PTC) by combining familiesof Benzemidazole and Oxazoline was developed to synthesis two newderivatives. The melting point and Thin Layer Chromatography (TLC)was used verified the purity of the two newly synthesized compounds,then to determine the structure, the analytical techniques of Infrared(IR) spectral studies and Spectroscopy Nuclear Magnetic Resonance(1H NMR) were used. The synthesized compounds will be exposedlater to toxicity studies (acute and chronic) and then to psychotropic activity tests in the wayto show its psychotropic activities.

Keywords: 2-Mercapto-Benzemidazole, 2-Amino-Benzemidazole, Benzimidazole, Oxazoline, Oxazolidinone, Psychotropic, Phase-Transfer Catalysis, Diethyl-amine.