Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL PYRIDINE QUATERNARY ANALOGS

Sabahat Naeem*, Shamim Akhtar, Nousheen Mushtaq, Shaista Zafar,
Muhammad Arif

Abstract

Resistance to known antimicrobial drugs has continued to emerge as a global human threat which can be solved by the discovery of fresh candidates. In this regard, we hereby discussed the synthesis of novel analogs of 4-Pyridine carbohydrazide PCH (I) which was prepared by quaternizing this molecule with substituted phenacyl halides (II a-k). The obtained products were structurally characterized and then screened for their in-vitro antimicrobial potential against different bacteria and fungi. It was observed that some of the prepared derivatives exhibited moderate to good antibacterial activity where pphenyl and p-chloro substitutions induced activity in derivatives III a and III c against tested species of E. coli. Compound III a and III i was more active against Candida albicans than that of the standard antifungal drug Griseofulvin.

Keywords: Pyridine carbohydrazide, Phenacyl halides, Quaternization, Antimicrobial activity, Agar Well method, Structure Activity Relationship.