Abstract

RISK MARKERS FOR CARDIOVASCULAR DISEASE IN NORTH INDIAN TYPE II DIABETES MELLITUS- OBESE PATIENTS

Santosh K. Yadav, Awadhesh K. Arya*, Richik Tripathi, Kamlakar Tripathi

Abstract

Objective: To explore biochemical and lipid parameters in the serum of type 2 diabetes mellitus (T2DM) patients with obesity having cardiovascular disease from Northern India. Methods: We enrolled 450 subjects out of which 167 type 2 diabetes mellitus patients were obese having cardiovascular disease, 166 were obese with type 2 diabetes mellitus and 117 were type 2 diabetes mellitus patients without any complication. The circulating serum biomarker such as low-density lipoprotein, high-density lipoprotein, very low density lipoprotein, Triglyceride, Creatinine, Fasting blood sugar etc were analysed by biochemical methods and enzyme linked immunosorbent assay (ELISA). Results: The low density lipoprotein was significantly higher whereas reduced high density lipoprotein was observed in obese type 2 diabetes mellitus patients with cardiovascular disease as compared to T2DM and T2DM with obese patients. Conclusions: Significant differentiation in lipid profile and biochemical markers between all three groups shows that North Indian patients having T2DM and obesity are at higher risk of developing cardiovascular complications.

Keywords: Cardiovascular, Diabetes mellitus, Obesity, Lipid, Complications.