Abstract

EVALUATION OF MICRONUCLEI AS GENOTOXIC ASSAYS INDUCED BY DRUG DICLOFENAC IN THE FRESH WATER FISH, CIRRHINUS MRIGALA

S. Binukumari, V. Priyadarsini and J. Vasanthi*

Abstract

Fishes belonging to the species Cirrhinus mrigala were exposed to 2.8 per cent concentration of Diclofenac drug for 24, 48, 72, 96 hours and 10 days, 20 days and 30 days respectively. Bioassay studies were conducted to calculate 50 per cent mortality of Cirrhinus mrigala in 96 hour by exposing to different concentrations of Diclofenac drug. Blood was punctured from the gill and analysed for genotoxicological test. Among the different exposure periods, the frequency of micronuclei higher in 30 days exposure period compared to the control.

Keywords: Cirrhinus mrigala, genotoxicological.