Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING ALGINATE BEADS OF LAFUTIDINE BY IONOTROPIC GELATION METHOD

Dipika H. Patil* (B. Pharm) and Prashant S. Malpure (M.Pharm, Ph. D)

Abstract

The present investigation aim to formulate gastroretentive floating drug delivery system of lafutidine to prolong gasric residence time, target stomach mucosa and increase the bioavailability. Lafutidine a newly developed histamine H2-receptor antagonist, it is used in the treatment of gastric ulcers, duodenal ulcers and gastric mucosal lesions associated with acute gastritis and acute exacerbation of chronic gastritis. The calcium alginate beads prepared by ionotropic gelation method using sodium alginate, hydroxyl propyl methyl cellulose and sodium bicarbonate. The developed beads were evaluated for physical appearance, micromeritic studies, particle size analysis, drug entrapment efficiency, swelling index, buoyancy studies, percentage yield, Fourier transform infrared spectroscopy (FTIR) studies, DSC Study, In vitro drug release study. The optimized formulation (F3) at the end of 12 hr shows % CDR 89.66%. The drug release data fitted in kinetic data. The optimized formulation follows zero order release kinetic and accelerated stability studies were performed for optimized batch.

Keywords: Alginate beads, Lafutidine, Gastroretentive floating drug delivery system.