Abstract

FORMULATION AND EVALUATION OF SOLID NANO EMULSION OF FUROSEMIDE

Sujatha S.*, Siva Jyothi J., Krishnaveni M., Rami Reddy G. and Kishore Kumar K.

Abstract

The aim of the present work is to prepare solid nanoemulsion of apoorly water soluble drug Furosemide with aerosil as carrier. Based onsolubility studies and pseudo ternary phase diagrams, five liquidSNEDDS were prepared with selected systems in various proportionsand evaluated for self emulsification time, phase separation andprecipitation of the drug, robustness to dilution, percentagetransmittance, thermodynamic stability studies, droplet size, PDI andzeta potential. From the evaluation studies it was found thatformulation consisting of oleic acid(15.4%w/w), tween80(57.1%w/w),PEG400 (17.5%w/w) and drug(10%w/w) was stable and optimum andselected for preparation of S-SNEDDS. With selected optimumformulation solid nanoemulsion is prepared using aerosil as carrier in 1:2 ratio by adsorptiontechnique and evaluated for flow properties, drug content, effect of dilution, droplet sizedetermination, FT–IR studies, in–vitro drug release study and accelerated stability study for6 months. Prepared solid nanoemulsion showed “good” flow properties and 95.162±1.24%drug content. Reconstitution properties showed spontaneous nano emulsification with dropletsize 65.02 nm and PDI 0.648. Results of in-vitro dissolution revealed that % drug releasefrom solid nanoemulsion was higher than that of pure drug and marketed tablet. Results ofaccelerated stability study for 6 months showed that formulation was stable and no alterationin the dissolution rate was observed. The results of present study have proved the potential use of solid nanoemulsion to improve solubility and dissolution rate of poorly water soluble drug furosemide.

Keywords: Solid nanoemulsion, Aerosil, Dissolution rate, accelerated stability Study and Furosemide.