Abstract

EXPLORING PHARMACOLOGICAL SIGNIFICANCE OF PIPERAZINE SCAFFOLD

Rajashree A. Markandewar* and M. A. Baseer

Abstract

Piperazines and their heterocyclic analogues possess a number of interesting biological properties. Clinical trials have shown that these compounds reached reasonable plasma concentration and are welltolerated. For this reason they are an object of continuously growing interest amongst the scientists. The purpose of this review is to provide an overview of the pharmacological properties as well as therapeutic applications of piperazine depending upon the pattern of substitution on the piperazine ring and their presence in many widely used drugs. This article highlights an interrelationship of yield and other reaction dynamics for piperazine moity.

Keywords: Heterocycles, Piperazines, drugs containing piperazine ring.