Abstract

ANTIDEPRESSANT ACTIVITY OF METHANOL EXTRACT OF COMMELINA BENGHALENSIS LINN. WHOLE PLANT.

Nishan Chakrabarty, Tanvir Ahmad Chowdhury, Mohammed Shoibe, Mohammad Shah Hafez Kabir*, Md. Nazmul Hasan, Md. Hosne Mobarak Chowdhury, Md. Rakibul Hasan, Fahima Zaheed, Muhammad Abdulla Al Noman, Md. Abdullah
Al Masum

Abstract

Objectives: The present study was to investigate antidepressant action of the methanol extract of Commelina benghalensis. Methods: Leaves of C. benghalensis was extracted with pure methanol (MECB). The forced swimming (FST) and tail suspension (TST) tests were used as predictive animal models of antidepressant activity, where the time of immobility was considered. For in vivo tests, doses of 200 and 400 mg/kg body weight were used. Results: The extract also significantly decrease the duration of immobility in both animal models of antidepressant activity, forced swimming and tail suspension tests. In FST, mice treated with two doses of MECB (200 and 400 mg/kg) showed decreases in their immobility times, which was significant (131.17±2.75 and 108.70±1.14 respectively; p

Keywords: C. benghalensis, antidepressant, forced swimming test, tail suspension test, immobility.