Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF CINNARIZINE

Anchal Sharma* and Rajeev Garg

Abstract

Cinnarizine is an H1 antihistaminic drug used in the treatment of motion sickness, vomiting and vertigo. Vertigo and vomiting is a significant public health concern in many developed and developing countries. Thus formulating Cinnarizine mouth dissolving tablet would provide fast relief. But it is insoluble in water. So in this work an attempt was made to increase the solubility by using solid dispersion technique by using PVP K30 as a carrier and to formulate the mouth dissolving tablet. The solid dispersion was characterized for solubility, IR and XRD studies. Using solid dispersion and by adding superdisintegrants i.e SSG and crospovidone in different concentration mouth dissolving tablet was formulated. The tablet was evaluated for thickness, hardness, weight variation, friability, drug content, disintegration time and dissolution studies. The disintegration time was found between 22-52 second and the percent drug release was found 69.21-98.80. The results showed that solubility of Cinnarizne was successfully enhanced and formulated into an mouth dissolving tablet as an alternative to conventional tablets.

Keywords: Cinnarizne, Solid dispersion, PVP K30, crospovidone, SSG, Mouth dissolving tablet, IR,XRD.