Abstract

EXPLORATION OF ANTIDIABETIC ACTIVITY IN CASEARIA ELLIPTICA

*Chaitanya Sravanthi Kota, Dr. Hemanth Kumar V., Dr. Sunitha Reddy M.

Abstract

Diabetes, Obesity, Hypothyroidism, hyperthyroidism etc., are most common metabolic disorder in world population. Present research is carried out on one of the such metabolic disorder- Diabetes. A invivo study on bark of Casearia elliptica extract was conducted for evaluation of antidiabetic activity in STZ induced diabetic rats. 180- 200gms rats were administered with STZ dose 60 mg/kg to induce diabetes. Rats were grouped into five and five rats in each group. Group I (Normal group), Group II (Diabetic control- STZ), Group III (treated with Glibenclamide), Group IV (Casearia elliptica bark extract 200mg/kg).group IVA(400mg/kg Casearia elliptica bark extract). Glibenclamide (10mg/kg) is administered to Group III. Blood glucose in Group IV, III, II, I, on 14th day were 157.8 ± 4.44 & 138.2 ± 10.64(200 & 400mg/kg), 98.8 ± 2.59, 291±1.58, 107±1.67 respectively. The Observation showed that standard is one and half times more potent than Group IV in hypoglycemic effect at a dose of 200mg/kg. Body weights of Group IV, III, II,I and on 14th day were198.22±2.74 & 193.96 ± 3.82, 187.2±0.96, 165.8±1.2,193.5 ±3.43 and with no toxic effects were observed in the Test Group (Group IV). Body weights and blood glucose levels, ALP, SGOT & SGPT were compared with Group II. Tests for primary metabolites like Proteins, Carbohydrates were done and secondary metabolites like Steroids, Alkaloids, Saponins and Flavonoids were present in Casearia elliptica which were detected by preliminary chemical tests.

Keywords: Diabetes, Streoptozotocin, C. elliptica, Metabolic disorder.