Abstract

FORMULATION AND EVALUATION OF PUSH-PULL OSMOTIC TABLET OF CYPROHEPTADINE HYDROCHLORIDE

Bhairav Bhushan A.*, Wagh Yogesh B., Saudagar Ravindra B.

Abstract

Cyproheptadine is serotonin antagonist and histamine H1 blocker used as antipruritic, anti-allergic, appetite stimulant and for post gastrectomy dumping syndrome. Push-pull osmotic tablet of Cyproheptadine hydrochloride was developed using Sodium chloride as a key ingredient which gives osmogent property, which provides driving force from push layer (lower layer) inside the core tablet and which leads to release of drug from drug layer. Hydroxy propyl methyl cellulose was used as a release retardant material in the present work. Different formulations were prepared by varying the concentrations using 32 factorial design. It was applied to see the effect of variables Sodium chloride and HPMC on the response percentage drug release as a dependent variable. These formulations were evaluated for, Hardness, Flow property, Thickness, Friability, Drug content and In-vitro drug release. Tablets were coated with a semipermeable membrane using 10% w/v cellulose acetate in acetone and PEG 400(5%) used as Plasticizer. Coated Push-pull osmotic tablets were drilled for delivery orifice using standard micro drill of diameter size 0.6 mm on drug layer coated surface. Drug release rate was increased as the increase in the concentration of sodium chloride and release rate decreased on increasing the concentration of HPMC. SEM Study was carried out for detection of diameter size of delivery orifices. The FTIR studies demonstrate that there was no interaction between polymer and drug. The optimized formulation was stable for 3 months of accelerated stability study.

Keywords: Cyproheptadine, HPMC, Nacl, Push-pull Osmotic Tablet.