Abstract

MOLECULAR MECHANISMS OF MYOCARDIAL PRECONDITIONING: AN OVERVIEW

*Gurfateh Singh, Iqbaljit Kaur, Ankur Rohilla

Abstract

The condition in which the coronary blood flow to the heart gets abbreviated resulting in scarce oxygen and nutrients supply to the myocardium is referred to as myocardial ischemia. The reperfusion to the ischemic myocardium results in lethal myocardial injury known as myocardial ischemia-reperfusion (I/R) injury. The phenomenon of myocardial preconditioning involves the application of brief episodes of ischemia and reperfusion given before prolonged ischemia and reperfusion. However, preconditioning is an anti-jeopardized phenomenon which protects the myocardium from lethal I/R-injury. In this review, we have critically discussed the mechanisms involved in the cardioprotective effects of preconditioning to limit I/R-reperfusion induced myocardial injury. In addition, various types of myocardial preconditioning have been conversed in the review.

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