Abstract

DENDRIGEL: PREPARATION, OPTIMIZATION AND CHARACTERIZATION

*Amanjot, Shalu Rani, Harjaskaran, Lovepreet Singh, Surya Prakash Gautam and Sukhbir Kaur

Abstract

The preparation of dendrigel, using dendrimers as drug carrier. Dendrimers were prepared by divergent method and was loaded in varying proportion in carbapol 940. To this mixture itraconazole drug was added and the formulation of dendrigel was evaluated. Dendrimers was prepared by divergent growth method. Evaluation parameter such as colour test, UV spectroscopy, FT-IR. Evaluation parameters for dendrigel were pH, spreadability, viscosity, drug content, antifungal activity and in vitro release studies. The prepared dendrigel having better antifungal activities than other conventional delivery system because dendrimers were enhance the solubility of drug which results in increase in penetration of drug in the skin.In the present study attempt was made to develop dendrimers containing itraconazole as a drug so as to increase the solubility and penetration of the drug through the skin using novel delivery system for better antifungal activity.This will help to increase the solubility and penetration of drug. It increases the antifungal activity of formulation.

Keywords: PAMAM, dendrimer, dendrigel, nanoparticles, FT-IR, UV spectroscopy.