Abstract

ANTINOCICEPTIVE ACTIVITY OF METHANOL EXTRACT OF COMMELINA BENGHALENSIS LINN. WHOLE PLANT.

Tanvir Ahmad Chowdhury, Mohammad Shah Hafez Kabir*, Md. Ismail Hossain, Mohammed Farhad, Tanzina Rahman, Raianul Haque, Md. Sajjad Ul Hoque, Nishanm Chakrabarty, Mahmudul Hasan, Md. Mominur Rahman

Abstract

Objectives: The present study was to investigate anti-nociceptive action of the methanol extract of Commelina benghalensis. Methods: The animals were submitted to acetic acid-induced writhing test and Formalin induced licking test to assess antinociceptive activities, respectively. Two doses 400 and 200 mg/kg were administered for testing. Results: The methanol extract of C. benghalensis at both doses, exhibited a significant (p < 0.05 - < 0.01) dose-dependent antinociceptive activity in acetic acid writhing test and Formalin test. In acetic acid-induced writhing test, oral administration of CB (200 and 400 mg/kg) also decreased the writhing significantly while compared to control. The dose 400 mg/kg showed maximum percentage of pain inhibition 52.24% and 64.29% for respectively. Diclofenac sodium (10 mg/kg) was used as reference antinociceptive drugs. Conclusions: The leaf extract has potential antinociceptive activity. The present study supports the use of C. benghalensis in different depressive states.

Keywords: C. benghalensis, anti-nociceptive, Acetic acid writhing test, Formalin.