Abstract

AN OVERVIEW ON 5-NITROIMIDAZOLE DERIVATIVE “SATRANIDAZOLE”

Abhay Bhardwaj*, Daksh Bhatia and Anuj Pathak

Abstract

Precious role of nitrogen containing heterocyclic drugs has been available from ancient time for the treatment of microbial infections. 5- nitroimidazoles have widened exploration yet. Right now these agents used to cure sever treatment like anaerobic pathogenic bacteria and protozoa. 5-nitroimidazoles are a well-established group of antiprotozoal and antibacterial agents that inhibit the growth of both anaerobic bacteria and certain anaerobic protozoa, such as Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. Satranidazole is a type of antiprotozoal drug which belongs to the 5- nitroimidazole group. It is highly effective, well accepted and clinically useful against protozoa. It is two times more active than other nitroimidazole against amoebiasis and giardiasis. It is also more active against anaerobes than other nitrogen containing imidazoles. The present review provides a brief account of various works already done on satranidazole drug.

Keywords: HPLC, HPTLC, Satranidazole, Metronidazole, UV.c