Abstract

STUDY OF HISTOPATHOLOGICAL CHANGES AND CARBOHYDRATE METABOLIC PROFILES IN DIABETIC TESTIS TISSUE TREATED WITH ALOE VERA LEAF GEL EXTRACT

Dr. Ravi Naik Mude*

Abstract

Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex. In this study, histopathological changes and the carbohydrate profiles in Alloxan-induced diabetes in rats treated with the leaf gel of Aloe vera ethanol extract on was evaluated. Twenty four male rats were used in the study by allocating them into four groups, each of six rats. Control rats, control rats + Aloe vera, diabetic rats, diabetic + Aloe vera. Diabetes was induced intraperitoneally using 40 mg/kg body weight Alloxan. Aloe vera leaf gel extract administered orally to different groups of rat at a dose of 300 mg mg/kg body weight. The experimental period was 21days. The parameters studied are total carbohydrates, glycogen and glucose and histopathological changes of testis were investigated compared to the control group. These metabolic profiles were decreased in diabetic rats, expect glucose. Whereas, with Aloe vera extract treatment in diabetic rats these carbohydrate metabolic profiles were increased and glucose decreased. The observed reductions in carbohydrate metabolic profiles during diabetic condition in testis tissue may be due to the alterations in the carbohydrate metabolism. Aloe vera is capable of producing free radicles, which in turn cause damage to the cellular compartment system of rat.

Keywords: Diabetes, Aloe vera, Alloxan, testis, carbohydrate metabolic profiles and histopathology.