Abstract

SYNTHESIS AND ANTIOXIDANT ACTIVITY OF UREA AND THIOUREA DERIVATIVES OF GLY/PRO CONJUGATED 2, 3- DICHLOROPHENYL PIPERAZINE

D. M. Suyoga Vardhan, H. K. Kumara, M. B. Sridhara and D. Channe Gowda*

Abstract

The present research work involves the synthesis and antioxidant studies of urea and thiourea derivatives of glycine and proline conjugated 2,3-dichlorophenyl piperazine. The structures were confirmed by physical and spectroscopical measurements and the molecules were subjected to in vitro antioxidant studies by three different methods viz., DPPH, DMPD and ABTS radical scavenging methods. Interestingly compounds 1g, 1h, 2g and 2h bearing OCH3 particularly at para position found to be most active. On the basis of results obtained a few interesting structure activity relationships were ascertained.

Keywords: Amino acids, Piperazine, Conjugation, Urea/thiourea, Antioxidant.