Abstract

CYCLODEXTRIN-BASED NANOSPONGES: OPTIMIZATION OF REACTION CONDITIONS AND COMPLEXATION WITH HYDROPHILIC AND LIPOPHILIC DRUGS

Chirag J. Patel*, Dharmik M. Mehta, Pragna K. Shelat, Punit B. Parejiya, Hetal K. Patel and Arunkumar Shukla

Abstract

The aim of this work was to optimize the reaction conditions for synthesis of cyclodextrin nanosponges and to evaluate the capacity of the nanosponges to incorporate molecules within their structure using drugs with different structures and solubilities. Cyclodextrin Nanosponges (CDNS) as nanoporous materials for possible use as carriers for drug delivery were prepared from β-cyclodextrins and diphenyl carbonate (DPC) using stirring and sonication process. The structure of β-cyclodextrin-based nanosponges was principally investigated by FT-IR, DSC and XRD analyses. Sizes and morphology were also examined. Phase solubility and Solution state interaction studies were carried out to assess interactions with drugs. CDNS and Drug complexes were optimized for stirring speed / sonication frequency, reaction time and polymer: crosslinker ratio. The nanosponges were found capable of carrying both lipophilic and hydrophilic drugs and of improving the solubility of poorly water-soluble molecules.

Keywords: Nanosponge, Cyclodextrin, Gemcitabine HCl, Bicalutamide, Letrozole, Paclitaxel.