Abstract

FORMULATION OF COLON TARGETED PRESS COATED TABLETS OF CAPECITABINE BY USING NATURAL POLYMERS AND ITS INVITRO EVALUATION.

Akshay Thorat*, Rohit Shewale, Rajesh Jagtap and Rajendra Doijad

Abstract

The aim of the present work was to formulate and evaluate colon targeted drug delivery system (CTDDS) of capecitabine tablets using natural polymers such as Guar gum, Xanthan gum and Psyllium husk alone in combination with HPMC K-100. Tablet was prepared by press coated method. The basic idea behind the dosage form is to target the organ that is colorectal cancer and maintain lag time. To investigate effect of coating design on lag time and drug release from directly compressed tablet. The compatibility of drug and optimized formulation were determined by differential scanning calorimeter, FTIR spectroscopy and X-ray diffraction patterns. The precompression evaluation of coating material like angle of repose, bulk density, tapped density, Hauser’s ratio, flow property and also post-compression studies of core and coat tablet for hardness, thickness, friability, weight variation studies. It was observed that the increasing or decreasing concentration of polymer blend had affected on the drug release. As we increases the concentrations of polymer blend the lag time increases & vice versa. The results of in-vitro drug release studies showed that formulation (F2) has better drug release after 6 hrs. Lag time.

Keywords: Capecitabine, CTDDS, Press coated tablets and In-vitro study.