Abstract

DESIGN, SYNTHESIS& EVALUATION OF ANTIHYPERTENSIVE ACTIVITY OF 2-{4-(SUBSITUTED ARYL) PIPERAZINE-1-YL}-3-(4- HYDROXY PHENYL) QUINAZOLINE-(3H)-ONE DERIVATIVE

Dr. L. A. Kawale, Lokande Sonali, Sujata Yadav* and Kaveri Ahire

Abstract

In the present work, six novel 2-[4-(substituted aryl)piperazine-1-yl]-3- (4-hydroxy phenyl)quinazolin-4(3H)-one were synthesized by condensation, it is condensation between 3-(4-hydroxy phenyl )2- chloro,4(3H)quinazolinone and substituted substituted piperazine to yield 2-[4-(substited aryl)piperazine-1-yl]-3-(4-hydroxy phenyl)quinazolin-4(3H)-one derivatives. The structures of the synthesized compounds were characterized on the basis of IR, NMR and Mass spectral data. Among all synthesized compounds only few selected compounds are screened for their antihypertensive activity by tail-cuff method, Prazocin is employed as a reference standard. From the results it is concluded that, compound III and IV exhibited potent, rest of compounds exhibited mild to moderate activity antihypertensive activity.

Keywords: Piperazine derivative, Quinzoline, Antihypertensive activity, 3-(4-hydroxy phenyl) 2,4(3H) Quinazolindione.