Abstract

PREPARATION AND CHARACTERIZATION OF POLY (Ɛ-CAPROLACTONE) NANOSUSPENSION CONTAINING SATRANIDAZOLE

Abstract

The main aim of this research is to design a new system to incorporate the drug into the body ie. nanosuspension of satranidazole.Poly(ɛcaprolactone) nanosuspension were prepared by solvent displacement method and were characterized in terms of particle size, zeta potential, polydispersity index,in vitro drug release,and drug entrapment efficiency,stability studies. Nanosuspension of different drug and polymer ratio were formulated for the purpose of optimization.The nanoparticles have a particle diameter as 241.6 nm and a zeta potential 21.3 mV. There was a steady increase in the entrapment efficiency on increasing the polymer concentration in the formulation.Formulation NS1a was considered as optimum batch as it delivered 67.90 % of drug into colon. No appreciable difference was observed in the drug content of product during 60 days in which nanoparticles were stored at 4˚C and room temperature. According to the data obtained, this delivery system opens new and interesting perspectives way to formulate the nanosuspension of satranidazole.

Keywords: Nanoparticulate suspension; Satranidazole; PCL, Bioavailability.