Abstract

EFFECT OF WHEATGRASS JUICE ON REDUCED GLUTATHIONE AND GLUTATHIONE RELATED ENZYMES IN LUNG CANCER PATIENTS DURING CHEMOTHERAPY

Sachin Sharma*, B. R. Shrivastav and Archana Shrivastav

Abstract

Lung cancer is one of the major forms of cancer now days, leading to a large number of deaths throughout the world. Oxidative stress has been reported in most of the cancers including lung cancer. In the present study significantly decreased levels of reduced glutathione (4.54±0.68), glutathione peroxidase enzyme (3.50±0.11) and glutathione reductase enzyme (3.21±0.22) has been reported as compared to healthy controls. The levels of of oxidative strees also increases significantly during chemotherapy as the levels of reduced glutathione decreases to (3.46±0.34), glutathione peroxidase (2.92±0.26) and glutathione S transferase (2.80±0.25) after 3 cycles of chemotherapy. Wheatgrass juice during chemotherapy was found to be a natural antioxidant supplement during chemotherapy which decreases the levels of oxidative stress during chemotherapy and increases the effectiveness of chemotherapy drugs.

Keywords: Oxidative stress, Reduced Glutathione, Glutathione peroxidase, Glutathione S transferase, wheatgrass, chemotherapy.