Abstract

DESIGN AND EVALUATION OF ULTRADEFORMABLE SOFT ELASTIC NANO VESICLE ETHOSOMES FOR DERMAL DELIVERY

*Ajay Samnani¹, kundlik Girepunje², Mithun Bhowmick¹, Amit Joshi¹, B.K. Dubey¹

¹TIT College of Pharmacy, Bhopal (M.P.)

²Peoples Institute of Pharmacy, Bhopal, (M.P.)

Abstract

Clotrimazole is an antifungal drug for treatment of cutaneous candidiasis infections. However its oral administration is associated with number of drawbacks. The goal of the current investigation is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing clotrimazole an antifungal having limited transdermal permeation. clotrimazole loaded ethosomes were prepared, optimized and characterized for vesicular shape and surface morphology, vesicular size, size distribution, entrapment efficiency, and stability. The ethosomal formulation (E6 having 3% phospholipids content and 35% ethanol showing the greatest entrapment (58.75%). Stability study was performed for 120 days. Further more ethosomal delivery system could be considered for the treatment of number of dermal infections with better efficiency.

Keywords: Enhanced drug delivery, ethosomes, candidiasis, TEM, vesicle.