Abstract

THE STRUCTURAL MODIFICATION CAUSES THE ENHANCEMENT OF ANALGESIC ACTIVITY OF 4-HYDROXY 4- PHENYL PIPERIDINE ALONG WITH AN EXCELLENT INTERACTION WITH DIGESTIVE ENZYME, LEADING GOOD ADME

Kiran Rafiq*, Zafar Saied Saify, Asghari Ghous, Shazia Haider , Nighat Sultana

Abstract

The marvelous position of piperidine analogues has proven them an important core in the structures of therapeutically active molecules, pharmaceuticals and as synthetic intermediates with attractive biological and pharmacological behaviors. The piperidine ring containing compounds like pethidine and fentanyl have established as potent opiod analgesics. Due to similarity in structure, the present study was aimed to estimate the analgesic activity of synthesized derivatives of 4-Hydroxy-4-Phenyl Piperidine. The study was conducted in animal model, mice by using Pethidine as standard drug by hot plate method and analgesia was observed, furthermore the compounds were also analyzed for their interaction with digestive enzyme, amylase through agar plate method. The result illustrated the more high up response of substituted compounds than the parent one “4-hydroxy-4-Phenyl Piperidine” and by studying the structural activity relationship it was concluded that the modification in structure of the parent molecule is accountable for a better and positive pharmacological activities. Hence the synthesized derivatives will prove as potent analgesics with strong interface with amylase enzyme.

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