Abstract

EFFICACY OF NEW OXCARBAZEPINES ANALOGUES FOR ANTI CANCER DRUGS INDUCED NEUROPATHY PAIN IN RATS

*Aziz-ur-Rahman and Sayyed Abdul Mateen

Abstract

Neuropathic pain in cancer patients remain a treatment challenge for health care industry. Many treatments are used to prevent chemotherapy induced neuropathy. Some of the treatment so for tried are Antidepressants, Anticonvulsant, Steroids, Vitamin E supplements, Patches or creams of numbing medicines such as examples lidocain and Capsaicin creams and infusion of calcium and magnesium injections. Study results have been mixed for all these treatments so for, there is no sure way to prevent chemotherapy induced neuropathy (CIN) and more research is needed to treat this condition. Because of the limitation of the available treatment, new agents that are effective and safe should be explore and investigate through research for CIN treatment. Oxcarbazepine is a relatively novel anticonvulsant drug derived form Carbamazepine. It has fewer side effects and less drug -drug interaction then carbamazepine, because it is metabolised by non –CYP450 pathway. To potentiate the activity of oxcarbazepine against neuropathy pain, six analogues were synthesized by changing the keto group of 10th position and NH2 group of 5th position with different groups. Then synthesized oxcarbazepine analogues were screened for neuropathy pain. Paclitaxel (Taxol) 2mg/kg was used to induce neuropathy pain in rats for control and testing groups. The six synthesized analogues were given in the dose of 50mg/kg, then evaluation of the drugs done by hot plate and Randall Selitto test respectively. Among the six analogues, four were shown activity against chemotherapy induced neuropathy pain where as remaining two were not significant in the above parameters tested.

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