Abstract

EVALUATION OF ANTHELMINTIC ACTIVITY OF CRUDE EXTRACTS AND DIFFERENT FRACTIONS OF STEM BARK AND FRUITS OF OROXYLUM INDICUM

Majedul Islam*, Md. Mahfuzur Rahman, Mahmudul Hasan, Md. Moksadur Rahaman, Md. Rasal Hossain Khan and Abdullah-Al-Faysal

Abstract

Helminths are most common infectious agents of humans in developing countries, but current medications to control the worm infections are limited due to lack of lucrative market place and little knowledge about the unique biochemical metabolism of parasitic worms.[1,2] In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree.[3] Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine.[4] The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. The anthelmintic activity of methanolic bark and fruits extract of Oroxylum indicum caused paralysis at 8.8 min and 9 min respectively and time of death were 13.4 min and 14 min respectively with 100 mg/ml against the earthworm Pheretima posthuma. The standard drug Albendazole at 10 mg/ml conc. showed the same at 4.1 and 6.8 min. respectively. This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant anthelmintic activity.

Keywords: Helminths, Oroxylum indicum, antihelmentic, methanolic extract.