Abstract

FORMULATION OF IN-SITU GELLING OPHTHALMIC DROPS OF MOXIFLOXACIN

Ashwini Mahadeo Chincholkar*, Tanaji Dilip Nandgude, Sushilkumar Sharatchandra Poddar

Abstract

The aim of the present work was to obtain an ophthalmic delivery system with improved mechanical and mucoadhesive properties that could provide prolonged retention time for the treatment of ocular diseases. The most frequently used dosage forms i.e. ophthalmic solutions and suspensions are compromised in their effectiveness by several limitations, leading poor ocular bioavailability. In-situ gels are instilled as drops into the eye and undergoes a sol to gel transition in the cul-de-sac, improved ocular bioavailability by increasing the duration of contact with corneal tissue, thereby reducing the frequency of administration. The purpose of the present work was to develop pHtriggered an ophthalmic drug delivery system using combination of gelling agents with different mechanisms for in-situ gelation of Moxifloxacin. In-situ gels were prepared by simple dispersion method using carbopol 940 along with HPMC E15 LV in factorial design and then evaluated for pH, gelling capacity, drug content, Viscocity, and in-vitro dissolution studies and Muccoadhession study. Among formulation batches F1- F9; optimized formulation F7 imparted sustained release property to the gel formed in-situ and effective other evaluation parameters. The developed formulations were therapeutically efficacious, stable, non-irritant and provided sustained release of the drug overcoming convential drawbacks leading to better patient acceptance.

Keywords: In-situ forming systems; ophthalmic In-situ gel; Moxifloxacin; carbopol 940, HPMC E15 LV.