Abstract

FORMULATION AND EVALUATION OF EXTENDED RELEASE MUCOADHESIVE MICROSPHERES OF ATORAVASTATIN CALCIUM BY SPRAY DRY METHOD

Mallavarapu Peddareddy*, Batta Nagendrababu, Dr. D. Jeevan Mani Babu and M. Rama Krishna

Abstract

The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of Atorvastatine calcium. Atorvastatine calcium microspheres were prepared by spray dry technique. Drug atorvastatine calcium is the ideal candidate for Gastroretentive mucoadhesive formulation because of its short half life, stability in to the gastric pH. Gastroretentive mucoadhesive formulation of atorvastatine calcium was developed by spray dry technique using various concentrations of polmers in combination and they were evaluated for production yield, Particle size determination, Surface morphology, Percent drug entrapment efficiency, swelling index, in- vitro drug release study, in-vitro mucoadhesion study. Oral bioavailability of atorvastatin calcium (ATC) is very low (only 14%) due to instability and incomplete intestinal absorption and/or extensive gut wall extraction. So our aim is to increase the bioavailability of atorvastatine through mucoadhesive formulations orally, along with would achieve a substantial increase in the length of stay of the drug in GI tract. After analyzing different evaluation parameters including drug release kinetics and mucoadhesion, formulation F-3 having Among all the fabricated formulation, F3 (Drug:Carbopol:Hpmc = 1:1:2) was chosen as an ideal formulation showing an extended drug release over a period of 8h (97.11%) with acceptable entrapment efficiency (78%) and mucoadhesive property.

Keywords: Atorvastatin calcium, mucoadhesive microspheres, polymers, factorial design.