Abstract

DEVELOPMENT AND EVALUATION OF NSAID TOPICAL GEL USING DIFFERENT PERMEATION ENHANCERS

Md. Mazher Ahmed*

Abstract

Nimesulide is a COX-2 specific, non-steroidal mitigating drug (NSAID) with analgesic and antipyretic properties. Topical gel formulations of nimesulide were produced by utilizing gel framing specialist like Carbopol 934P. Tween 80, Eucalyptus oil, Almond oil and Eudragit were utilized as entrance enhancers. Glycerin was utilized as a humectant. The gel definitions were characterized by IR study recommended that the plan arranged is a physical blend. The readied gel definitions were assessed for drug content, pH and rheological parameters like viscosity, spreadability and extrudability. The percent release of nimesulide from plain gel was moderate when contrasted with other medication stacked gel definitions. The plan (F11) demonstrated most extreme percent discharge (99.56%). The Gael plans were assessed for in vitro penetration study about the detailing, containing 2% Eudragit demonstrated most astounding saturation contrasted with different definitions. Stability studies of selected gel formulations were performed to assure that the formulation retains its activity. The formulations were found to be stable. Hence, from the overall study it can be concluded that nimesulide gels along with different penetration enhancers can be prepared to improve the permeation through the skin surface.

Keywords: Nimesulide; Eudragit; Eucalyptus oil; Almond oil; Tween 80, Penetration enhancers.