Abstract

IN-VIVO TRACKING OF BONE MARROW MESENCHYMAL STEM CELLS BY GOLD NANO TRACERS IN MUSCULOSKELETAL TRAUMA.

Perumal Saraswathi*, Nirmal Kumar. K, Kalyanapanchakshari. P, Saravana Kumar. S, Balaji Karuppaiah

Abstract

Stem cells are multifaceted. On treating injuries, they behave as a promising facts to retain normal tissue structure and function. Once the stem cells are injected, do they reach their intended target? Will they remain at the traumatized site? How many Tracking cells actually stayed? How many diffused or died? These are all the important questions remains to be answered. The important therapeutic potential of BMSCs is their ability to migrate to site of inflammation/stress, where they balance the situation through molecular mechanism of the P38MAPK pathway. This study aims tracking of bone marrow mesenchyme cells with non-cytotoxic gold nano tracers in treatment of various therapeutic applications.

Keywords: Mesenchymal Stem Cells (MSCs), Gold Nano particles (AUNPs), computed tomography (CT), Magnetic resonance imaging (MRI), Musculo skeletal trauma (MST), Transmission Electron Microscopy (TEM).