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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.453

ICV : 90.8

WJPR Citation

	All	Since 2020
Citation	8502	4519
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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

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Abstract

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL DIARYL IMIDAZOLES AS ANTI-INFLAMMATORY AGENTS

Dushyanth Reddy Vennapu and Palled M. S.*

Abstract

The synthesis and pharmacological activity of a new series of diarylimidazoles as potent selective COX–2 inhibitor were described. QSAR based approach to screen molecules using Schrodinger Maestro program to optimize the lead compounds against the murine cyclooxygenase receptor. The best fit ligand molecules based on the dock score were synthesized characterized and evaluated for their invivo anti-inflammatory activity using carrageenan induced paw oedema.

Keywords: 1, 5 - diarylimidazoles, selective COX â€“ 2 inhibitor, carrageenan induce paw oedema.

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