Abstract

FORMULATION AND EVALUATION OF TOPICAL MICROSPONGES OF SERTACONAZOLE

Arpita Sharma*, Aashima Hooda and Hema Chaudhary

Abstract

Current research was done to develop a topical formulation withcontrol relase of drug, reducing the side effects associated with topicaldrug delivery and improve the efficacy of product with aid ofmicrosponges. Cream containing microsponges loaded withsertaconazole nitrate were prepared by using quasi emulsion solventdiffusion with different proportions of the polymer (Ethyl cellulose).The developed microsponges were analyzed for particle size,production yield, entrapment efficiency and drug content. Scanningelectron microscopic images of microsponges revealed that they arespherical in shape and contain pores. Pore structure analysis was doneby using mercury intrusion porosimetry technique, which confirmedthe porous nature of microsponges. Microsponges were thenincorporated in to a 2% cream and evaluated for pH, drug content, spreadability, viscosityand in vitro drug release. The batch F6 was found to be optimal as it shown 70% controlleddrug release in 9 hr that followed Higuchi model.

Keywords: microsponges, ethyl cellulose, sertaconazole nitrate, cream.