Abstract

CALOTROPIS GIGANTEA LATEX EXHIBITS ANTIOXIDANT POTENTIAL IN DALTON’S ASCITES LYMPHOMA (DLA) BEARING MICE

Saswata Sanyal, Pralay Maity, Ananya Pradhan, Madhubanti Bepari, Surya Kanta Dey, Sujata Maiti Choudhury*

Abstract

Calotropis gigantea of family Asclepiadacea traditionally used in ayurveda for its anti-helminthic, anti-pyretic and anti-malarial activities. It has also been studied widely for its anticancer potential. The aim of the present study was to evaluate the antioxidant properties of Calotropis gigantea latex in Dalton‟s ascites lymphoma (DLA) bearing mice. The ethanol and water extracts of Calotropis gigantea latex (EECGL and WECGL respectively) were administered at a 100 and 200mg/kg body wt. for 14 days, 24 h after the inoculation of tumor cell line. Hepatic and renal malondialdehyde (MDA), reduced glutathione (GSH) and the activities of glutathione peroxidase (GPX), glutathione-s-transferase (GST), catalase (CAT), superoxide dismutase (SOD) were measured. Treatment with EECGL and WECGL significantly reduced the elevated levels of MDA and increased the reduced levels of GSH, GPx, GST, CAT and SOD activities in DLA induced mice compared to those of DLA control group animals. The results conclude that the ethanol and water extract of Calotropis gigantea latex possess significant antioxidant effects in DLA bearing mice.

Keywords: Calotropis gigantea, Dalton?s Ascites Lymphoma (DLA), Antioxidant, Hepatic and renal malondialdehyde.