Abstract

STUDYING THE EFFECT OF CHANGING PLASTICIZER ON THE FORMULATION OF MUCOADHESIVE BUCCAL PATCHES OF CAPTOPRIL

Nawal A. Rajab* and Zainab Ahmed Sadeq

Abstract

Drug delivery through buccal mucosa is a novel method for local and systemic treatment because buccal mucosa is permeable with rich blood supply and allow long- time retention of dosage from. The objective of this study is to prepare captopril as mucoadhesive buccal patch by solvent casting method and studying the effect of changing plasticizer type and increasing the drug amount on the physical and mechanical behavior of film and in vitro drug release study .The patch was prepared using hydroxylpropyl methyl cellulose K4 (HPMC) as patch forming polymer with secondary polymer (carbopol 934) and propylene glycol as plasticizer (30% of total polymer weight). The patches were prepared by solvent casting method and evaluated for weight variation, surface pH, mechanical properties, content uniformity, ex-vivo mucoadhesive strength and in-vitro drug release study. Formula F5containing HPMC as primary polymer with carbopol 934 as secondary polymer was chosen as selected formula since Surface pH(6.44), Tensile strength (16.06), percentage Elongation at break (34.14), Ex-vivo residence time (hrs) 6.12±0.06, Mucoadhesive strength(26.2gm)with invitro drug release around 94.73% of 6hrs. The research showed in-vivo drug release of 73.12% of captopril released after 6hrs for selected formula with acceptable correlation (R2) value of (0.986) suggesting successful formulation that can be used to increase patient accessibility, increase the residence time of drug at absorption area which leads to increase drug absorption and avoidance of first pass metabolism that leads to increasing the drug bioavailability.

Keywords: Captopril, buccal patches, mucoadhesion, propylene glycol.