Abstract

IMMUNOMODULATORY ACTIVITY OF DICHCLOROMETHANE EXTRACT OF SPINACIA OLERACIA AND METHANOLIC EXTRACT OF DESMODIUM TRIFLORUM

Namrata Singh*, Mukul Tailang and S.C. Mehta

Abstract

The dichloromethane extract of Spinacia oleracea leaves and methanolic extract of Desmodium triflorum leaves was studied for immunomodulatory activity. The immunomodulatory effect was studied in delayed type hypersensitivity response using SRBCs, phagocytic reponse using carbon clearance assay and cyclophosphamide induced myelosuppression. Spinacia oleracea leaves extract and Desmodium triflorum leaves extract showed an increase in the hypersensitivity response, produced a significant increase in the phagocytic index and protection against cyclophosphamide induced myelosuppression indicating its effect on cell mediated immunity. From the above result, it was concluded that the dichloromethane extract of Spinacia oleracea and methanolic extract of Desmodium triflorum has a significant effect on both cell mediated and humoral immunity.

Keywords: analgesic and anti-inflammatory activity, anthelmintic action, anticonvulsant activity, antibacterial activity and antinociceptive activity.