Abstract

BRAIN TUMOR AND PASSIVE TARGETING

*Ojaswi Ghadge, Anubha Khale, Ajit Wankhede

Abstract

Insufficient drug delivery across the blood–brain barrier (BBB) has been a major challenge in the chemotherapy of brain pathologies.Various novel approaches have been developed for the accurate detection of early-stage of cancer like brain tumor and for its targeted therapies. Newly developed targeted therapies limits the unwanted toxicity to healthy cells. Various strategies of drug targeting like passive targeting are in limelight today. Main aim of this article is to review pathology of brain in presence of tumor, how the passive targeting has improved the survival rates in patients with brain tumors, understanding the phenomenon of active and passive targeting andto explore different parameters of drug candidate to be modified for its best use in passive targeting through nanoformulation.

Keywords: Brain tumor, passive targeting, blood brain barrier, targeted drug delivery, nanoparticles.