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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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ICV : 90.8

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Abstract

SYNTHESIS AND ANTIMICROBEAL ACTIVITY OF SULFONYL AND CARBOXAMIDE DERIVATIVES OF CYCLOPROPYL PIPERAZINE

Namdeo Bhujbal*, Dattatray Gaikwad, Neha Patil and Meghmala Waghmode

Abstract

A series of molecule containing di substituted piperzines are designed and synthesized. The structure of synthesized compounds were elucidated and confirmed by 1H NMR, LCMS and purity was checked through HPLC. Total 18 analogs were synthesized containing urea amide and sulfonamide linkage. The synthesized compounds are evaluated for their anti-bacterial activity against gram-positive and gram negative bacteria. The some of the sulfonyl and carbamaide derivatives showed excellent zone of inhibition against tested bacteria.

Keywords: Piperazine, carboxamide, sulfonylamide, E.coli, S.aureus.

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