Abstract

REVIEW ON PODOPHYLLOTOXIN: SOURCES, EXTRACTION, APPLICATIONS AND CURRENT PERSPECTIVES

Parul Sharma*, Abhay Kumar Verma, Sonia Chauhan, Somnath Kharwar and Priyanka Shrivastava

Abstract

Lignans are a class of secondary plant metabolites produced by oxidative β-β linked dimerization of two phenyl-propanoid units. Podophyllin resin obtained from ethanolic extract of Podophyllum peltatum and Podophyllum emodi belonging to family Berberidaceae, is a good source of the aryltetratin type lignin. Podophyllotoxin and its semi-synthetic derivatives exhibit several biological activities including antiviral and anti-neoplastic. Etoposide and Teniposide have emerged as successful antineoplastic agents after modifications of the basic skeleton in podophyllotoxin. The mechanistic studies and chemical manipulations to improve their bioactivity are still under investigation. The podophyllotoxin analogues have advanced in several therapeutic areas and developmental chemotherapy. Podophyllotoxin based multidrug regimens have been developed for better therapeutic efficacy.

Keywords: Lignans, Podophyllum, Podophyllotoxin, HPTLC.