Abstract

FORMULATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF AN ANTI DIABETIC DRUG

Donthureddy Sarika*, G. Rama Krishna and Syed Munner

Abstract

The present study involved, preparation of Glipizide floating microspheres to improve the bioavailability by increasing residence time in stomach. In preformulation study the drug Glipizide was subjected to various preformulation studies namely solubility, melting point. Micromeritic properties of the prepared microspheres were evaluated for bulk density, Carr’s index and angle of repose. Drug– polymer interaction was studied using FTIR analysis. The results showed that there were no changes in the IR spectra of pure Glipizide in the presence of Cellulose acetate and Cellulose acetate butyrate. Thus revealing compatibility of the selected drug with the polymer. Among the different Glipizide floating microspheres formulations, the formulation F1 was selected as the ideal formulation, based on its micromeritic properties, floating behavior, drug loading, drug entrapment efficiency and percentage of drug released for a prolonged period over 12h.

Keywords: Glipizide floating microspheres, Bioavailability, Micromeritic properties, Drug–polymer interaction, floating behavior, Drug loading, Drug entrapment efficiency, Percentage of drug released.