Abstract

SCREENING OF ANTIDIABETIC (HYPOGLYCEMIC/ANTIHYPERGLYCEMIC) ACTIVITY OF EXTRACTS OF SPIRULINA AGAINST ALLOXAN INDUCED DIABETES IN RATS.

Panigrahi B.B.*, Quamuddin M., Panda P.K. and Patro V.J.

Abstract

Spirulina is a cyanobacterium, blue green algae, belongs to cyanophyceal, a prokaryotic form. Spirulina was extracted through Pet- Ether, chloroform and methanol by Soxhlet’s extraction process. After making phytochemical analysis, duly confirmed through TLC proceeded for hypoglycemic activity. The antidiabetic activity of different extracts of spirulina was carried out using albino rats of either sex, diabetes was induced 12 hour fasted rats by intra peritoneal injection of alloxan. Rats with 250 mg/dl plasma glucose level were selected for experiment. Petrolium ether, Chloroform extract did not lower the blood glucose level. However Methanolic extract of Spirulina significantly reduced the blood glucose level. Standard drug used in this research study is Metformin.

Keywords: Spirulina, Petrolium Ether, Chloroform, Metformin, Methanolic extract.