Abstract

CLINICAL AND COMPARATIVE STUDY OF JATIPHALA AND JAVITRI IN HYPERPIGMENTATION

*Yasmin S., Dixit Renu and Reddy K.V.V. Bhaskara

Abstract

The clinical efficacy of seed and aril of Nutmeg (Myristica fragrans Houtt.) was evaluated in a randomized, single- blind, Placebo controlled study in patients with hyperpigmentation. After three months single blind run in period, 30 patients with hyperpigmentation were randomly allocated to receive either a drug treatment or matching placebo for a period of 3 months. Clinical efficacy was evaluated every forth night for three sittings or till the sign are relieved on the basis of parameters Varna, Khara and Parimana. Other parameters like Thyroid profile, complete blood count and ultrasound were carried out. Treatment with the seed and aril of Nutmeg produced a significant drop in Varna, Khara and Parimana. With in between in the group comparison was done Varna was statistically significant (F=6.613, p=0.0046, p>0.05). In between group comparison Khara was showed statistically significant (F=7.1632,P=0.0032,P>0.05) and finally in between Group comparison of Parimana also showed statistically significant (F= 7.019, P=0.0035,P>0.05) Side effects observed with this nutmeg did not necessity withdrawal of treatment.

Keywords: Ayurveda, clinical trail, Hyperpigmentation, Seed and Aril of nutmeg.