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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

DEVELOPMENT AND VALIDATION OF VISIBLE METHOD FOR ESTIMATION OF CILAZAPRIL IN BULK FORMULATION

Chavi Dagar, G. Rohit Reddy* and VVS. Rajendra Prasad

Abstract

A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with vanillin in the presence of conc.Sulphuric acid producing orange red colour chromogen which shows maximum absorbance at 580nm against reagent blank. The Chromogen obeyed Beer’s law in the concentration range of 10-50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.

Keywords: Cilazapril, vanillin (4%), conc.Sulphuric acid, Visible Spectrophotometric.

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