Abstract

DIURETIC ACTIVITY OF ETHANOLIC EXTRACT OF PLANT SOLANUM SURATTENSE SEEDS

Hemant Swami*, Mahendra Kumar Panigrahi and Supriya Pradhan

Abstract

In the present study the diuretic activity of ethanolic extract of seeds of plant Solanum surattense has been carried out. The dried seeds of Solanum Surattense were subjected to successive extraction using the solvents (Petroleum ether, Ethanol and water) in increasing order of polarity. The phytochemical studies such as determination of yield, extractive values and ash value have been performed. Phytochemical screening has also been performed for the detection of phytoconstituents. IR-Spectroscopy and TLC of ethanolic extract of S. surattense seed was also performed .The ethanol extract was selected for further study. The diuretic potential of ethanolic extract was assessed in albino rats using in-vivo Lipschitz test model. The volumes of urine, urinary concentration of sodium potassium and chloride ions were selected parameters for diuretic activity. Furosemide was used as standard and ethanol extract at 500 mg/kg body weight was used for diuretic activity. It was found that treatment with seed extract of S. surattense (ethanolic) markedly results in excretion of Na+, K+ and Cl- ions. The results show that the seed of Solanum surattense have diuretic activity as compared with Furosemide as standard drug.

Keywords: Solanum Surattense, seeds, Ethanolic extract, Diuretic activity, Furosemide.