Abstract

EFFECT OF LIPID COMPOSITION ON LIPOSOMAL FORMULATION OF PRAMIPEXOLE

Rashmi V. Trivedi*, Jayshree B. Taksande, Nishant B. Awandekar, Milind J. Umekar

Abstract

Treatment of Parkinson’s disease (PD) with non ergot dopamine agent, Pramipexole is popular due its advantages over Levodopa therapy. In the present investigations, Pramipexole containing liposomes were formulated to improve the efficacy of the treatment. The effect of varying concentration of cholesterol, soy lecithins and drug on the physical and chemical characteristics of the liposomes was investigated. Liposomal formulations containing varied amounts of Cholesterol, Soy lecithin and Pramipexole were prepared using thin film hydration method. All the formulations were characterized for shape, vesicle Size, TEM, zeta potential, soy lecithin content, percentage entrapment efficiency, in-vitro release studies and drug leakage studies. It was found that the increase in cholesterol concentration increased the vesicle size and percentage entrapment of drug, but the percentage drug release as well leakage of drug were decreased. Increase in soy lecithin concentrations exhibited increase in vesicle size and percentage entrapment of Pramipexole but decreased in vitro release and drug leakage. The concentrations of Pramipexole used however exhibited variable effects on characteristics of liposomes.

Keywords: Pramipexole, Soy Lecithin, Cholesterol, Liposomes.