Abstract

IMMUNLOGICAL SIGNATURES OF CURE IN EXPERIMENTAL VISCERAL LEISHMANIASIS FOLLOWING THE COMBINED IMMUNOCHEMOTHERAPY WITH PENTOSTAM AND TRE HALOSE DI MYCOLATE

Dr. Sabiha Imran*

Abstract

The purpose of this study to propose an alternative treatment to visceral leishmaniasis. Visceral leishaniasis is most neglected one of the top five parasitic diseases which is caused by Leishmanial donovani. The treatments which are available having toxic side effects and drug resistant cases also reported. To meet this purpose, Our work is based on the use of combined immunochemotherapy of tre haloes di mycolate and low dosages of pentostam and comparison the results from the higher standard dosage which has undesirable side effects .The studied was carried out by studying the immunological status of golden hamsters in infected and treated experimental hamsters by evaluating cellular and humoral immune responses. In the delayed type of hypersensitivity foot pad swelling in the infected animal was 11.6mm as compared to the treated with combined immunochemothrapy which was 8.4 mm. The results of macrophages migration inhibition test and DTH are in agreement to each other. ELISA and IHA titer values significantly reduced in in animals which were treated with combined TDM and Low dosage of pentostam as compared to the lower dosage alone.

Keywords: Visceral leishmaniasis, Combinatorial therapy, Tre haloes di mycolate, pentostam, Leishmanial donovani, immono-chemptherapy.