Abstract

GENETIC POLYMORPHISM IN THE METHYLENTETRAHYDROFOLATE REDUCTASE GENE ASSOCIATED WITH THE INCIDENCE OF ACUTE LYMPHATIC LEUKEMIA IN A SAMPLE OF IRAQI PATIENTS

*Zahraa Sahib Mohameed and Hameed Majeed Jassim

Abstract

Acute Lymphocytic Leukemia (ALL) is a type of leukemia that can be differentiate from other types of leukemia by the continuous multiplication and overproduction of immature and malignant white blood cells in the bone marrow. This study was aimed to investigated the relationship between the rs1801133 polymorphism in Methylenetetrahydrofolate reductase (MTHFR) with the susceptibility and severity of ALL, which was primarily diagnosed according to some blood clinical biomarkers. A total of 35 blood samples were collected from all patients of both genders with mean age of 36.5 years, and another 10 blood samples were also collected from apparently healthy controls with mean age of 33.5 year. results showed that there is a significant difference (p

Keywords: Methlenetetrahydrofolate reductase (MTHFR), Acute Lymphocytic Leukemia(ALL).