Abstract

TO STUDY THE IN VITRO ANTI-INFLAMMATORY ACTIVITY OF ACALYPHA INDICA LEAVES.

Yogesh K. Chaudhari*, Dr. Vijay A. Jagtap, Dr. Vanita G. Kanase, Imtiyaz Ansari

Abstract

The anti-inflammatory activity of the aqueous extract of Acalypha indica Linn. Family Euphorbiaceae. Leaves were evaluated by in-vitro method. Acalypha indica leaves were defatted with petroleum ether (60-800c) and soaked in water. Aqueous extract were screened for invitro activity at the doses of 200mg/kg 400 mg/kg and 600 mg/kg using Mizushima and Kobayashi method. Ibuprofen (100 mg/kg) were used as standard reference drug. The % inhibition of denaturation is produced by Acalypha indica linn extract at the dose 200mg/kg, 400 mg/kg and 600 mg/kg were 44.5%, 62.2% and 81.1% respectively when compared to control. The % inhibition of denaturation is produced by Acalypha indica linn extract at the dose 600mg/kg were comparable with that produced by Ibuprofen (85.71%) which indicates that Acalypha indica Lin. leaves extracts possess significant antiinflammatory activity.

Keywords: anti-inflammatory, indian acalypha, Kuppaimeni, Mizushima and Kobayashi method, petroleum ether.