Abstract

A FACILE SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF 2- PYRROLIDINONES DERIVATIVES

Rekha M. Patel, Sarju N. Prajapati and Kokila A. Parmar*

Abstract

2-Pyrrolidinones are one of the heterocyclic compounds with very important biological activites. In this view, it was proposed to synthesize some novel 2-Pyrrolidinones from Schiff bases. Here the synthesis of 2-Pyrrolidinones using 4-amino-N-(4-(2,4-dichlorophenyl)-6-(6- methylnaphthalen-2-yl)pyrimidin-2-yl)benzenesulfonamide and succinic anhydride under basic condition in presence of ethanol. The structures of synthesized were assigned on the basis of elemental analysis, IR and 1H NMR spectroscopy data. These compounds were screened for their anti-bacterial activity.

Keywords: 2-Pyrrolidinones, Antibacterial activity, Schiff bases.